| Cancer is a complex disease characterized by interactions between the tumor, microenvironment, and immune system. A broader and deeper understanding of the biology and signaling pathways that lead to cancer enables scientists to better identify, characterize, and target biomarkers that can ultimately be translated into clinical applications. Advances in molecular tools now enable a multiomic, holistic view of cancer that rapidly advances the understanding of how tumors develop, evade the immune system, and progress. |
|
The immune system often plays a role in the onset and progression of different disorders such as autoimmunity, fibrosis, and cancer. Understanding which cell types, cytokines, pathways, and transcription factors are involved in the balance between immune activation and suppression can lead to better treatments for chronic inflammation and disease. |
|
Neurodegeneration, neuroinflammation, infectious disease, and neurotrauma can have devastating effects on the Central Nervous System (CNS) that impact cognitive function, behavior, mental health, and more. Understanding the role of CNS cells such as neurons, astrocytes, glia, and oligodendrocytes as well as the pathways involved in disorders such as Alzheimer’s, Parkinson’s, Frontotemporal Dementia (FTD), Amyotrophic Lateral Sclerosis (ALS), and Multiple Sclerosis (MS) is crucial to disease prevention, detection, and treatment. |
